CHI Paediatric Formulary
CHI Paediatric Formulary
Prescribing and Administration Monographs
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Clinical Guidelines and Protocols
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Acute Hypotension/shock due to excessive vasodilation:
0.02 - 0.1microgram/kg/minute by continuous IV Infusion. Adjust dose according to response. Maximum 1 microgram/kg/minute.
Acute Hypotension/shock due to excessive vasodilation:
0.02 - 0.1microgram/kg/minute by continuous IV Infusion. Adjust dose according to response. Maximum 1 microgram/kg/minute.
The infusion must not be stopped suddenly but should be gradually withdrawn to avoid falls in blood pressure.
Contraindications: Hypertension
Cautions: Coronary vascular thrombosis; diabetes mellitus; following myocardial infarction; hypercapnia; hyperthyroidism; hypoxia; mesenteric vascular thrombosis; peripheral vascular thrombosis; Prinzmetal’s variant angina; susceptibility to angle-closure glaucoma; uncorrected hypovolaemia.
Monitor ECG & haemodynamic status.
Intravenous: Available as Noradrenaline 1mg/mL concentrate for solution for infusion.
Compatible infusion fluids: Sodium Chloride 0.9%w/v or Glucose 5% w/v.
Method of administration:
Continuous IV infusion via the CHI Standard Concentration Infusion (SCI) drug library:
The National Neonatal_SCI_Drug Library (a subsidiary of the CHI Paediatric SCI Drug Library) is in use in a number of neonatal units and by the National Neonatal Transport Programme (NNTP). Noradrenaline SCIs are the same across both libraries.
Note: May cause extravastation. Give via CVC where possible. Resite cannula at first signs of inflammation.
Caution in patients receiving MAOIs or within 14 days of cessation of such therapy and in patients receiving TCAs, adrenergic- serotoninergic drugs or
linezolid - severe, prolonged hypertension may result.
The use of pressor amines with halogenated anaesthetics may cause serious cardiac arrhythmias
Concomitant administration of propofol and noradrenaline may lead to propofol infusion syndrome (PRIS).
This list is not exhaustive. For full details see SPC
Hypertension, headache, bradycardia, arrhythmias, peripheral ischaemia, anxiety; dyspnoea; extravasation necrosis; hypovolaemia
This list is not exhaustive. For full details see SPC
Noradrenaline 1mg/mL Concentrate for Solution for Infusion (Hospira brand)
Note: Each mL of concentrate for solution for infusion contains noradrenaline tartrate 2mg, equivalent to 1mg noradrenaline base. Doses are expressed in terms of base.
Acute Hypotension/shock due to excessive vasodilation:
0.02 - 0.1microgram/kg/minute by continuous IV Infusion. Adjust dose according to response. Maximum 1 microgram/kg/minute.
Acute Hypotension/shock due to excessive vasodilation:
0.02 - 0.1microgram/kg/minute by continuous IV Infusion. Adjust dose according to response. Maximum 1 microgram/kg/minute.
The infusion must not be stopped suddenly but should be gradually withdrawn to avoid falls in blood pressure.
Contraindications: Hypertension
Cautions: Coronary vascular thrombosis; diabetes mellitus; following myocardial infarction; hypercapnia; hyperthyroidism; hypoxia; mesenteric vascular thrombosis; peripheral vascular thrombosis; Prinzmetal’s variant angina; susceptibility to angle-closure glaucoma; uncorrected hypovolaemia.
Monitor ECG & haemodynamic status.
Intravenous: Available as Noradrenaline 1mg/mL concentrate for solution for infusion.
Compatible infusion fluids: Sodium Chloride 0.9%w/v or Glucose 5% w/v.
Method of administration:
Continuous IV infusion via the CHI Standard Concentration Infusion (SCI) drug library:
The National Neonatal_SCI_Drug Library (a subsidiary of the CHI Paediatric SCI Drug Library) is in use in a number of neonatal units and by the National Neonatal Transport Programme (NNTP). Noradrenaline SCIs are the same across both libraries.
Note: May cause extravastation. Give via CVC where possible. Resite cannula at first signs of inflammation.
Caution in patients receiving MAOIs or within 14 days of cessation of such therapy and in patients receiving TCAs, adrenergic- serotoninergic drugs or
linezolid - severe, prolonged hypertension may result.
The use of pressor amines with halogenated anaesthetics may cause serious cardiac arrhythmias
Concomitant administration of propofol and noradrenaline may lead to propofol infusion syndrome (PRIS).
This list is not exhaustive. For full details see SPC
Hypertension, headache, bradycardia, arrhythmias, peripheral ischaemia, anxiety; dyspnoea; extravasation necrosis; hypovolaemia
This list is not exhaustive. For full details see SPC
Noradrenaline 1mg/mL Concentrate for Solution for Infusion (Hospira brand)
Note: Each mL of concentrate for solution for infusion contains noradrenaline tartrate 2mg, equivalent to 1mg noradrenaline base. Doses are expressed in terms of base.